Dose-Dense Therapy
نویسندگان
چکیده
منابع مشابه
Sequential dose-dense adjuvant therapy with doxorubicin, paclitaxel, and cyclophosphamide.
The recognition of paclitaxel's (Taxol) activity and non-cross-resistance with doxorubicin (Adriamycin) in the treatment of metastatic breast cancer has motivated study of the agent in the adjuvant setting. However, the ideal means of incorporating this new agent is not yet known. In stage IV disease, exciting results have been seen with combinations of doxorubicin plus paclitaxel, and this app...
متن کاملDose-dense paclitaxel-containing adjuvant therapy for breast cancer.
The use of dose-dense therapy is one approach to overcoming the "resistance" of malignant cells to adjuvant therapy caused by inadequate drug exposure. In this approach, active drugs are delivered sequentially at their "ideal" dose level separated by short intertreatment intervals. Thus, dose intensification is achieved by means of rapidly recycled treatments rather than by dramatic dose escala...
متن کاملDose-dense and sequential strategies in adjuvant breast cancer therapy.
Several attempts have been made to improve the survival rates of breast cancer patients. The benefit of adjuvant chemotherapy was clearly shown, but the absolute difference of 2% to 11% in overall survival, depending on the patient group, is disappointingly small. In particular, high-risk patients, such as those with > or = 10 involved lymph nodes, extracapsular spread, or vascular invasion, st...
متن کاملSequential Dose-Dense Adjuvant Therapy With Doxorubicin, Paclitaxel, and Cyclophosphamide
Despite the application of polychemotherapy, the majority of patients with node-positive early stage breast cancer ultimately experience relapse and die from their disease.[1] Two efforts that aim to increase the curative effect of systemic chemotherapy include increased dose-intensity and inclusion of non-crossresistant drugs or regimens. Because of paclitaxel's (Taxol) activity and clinical n...
متن کاملDose-dense and less dose-intense total therapy 5 for gene expression profiling-defined high-risk multiple myeloma
Multiple myeloma (MM) is a heterogeneous disease with high-risk patients progressing rapidly despite treatment. Various definitions of high-risk MM are used and we reported that gene expression profile (GEP)-defined high risk was a major predictor of relapse. In spite of our best efforts, the majority of GEP70 high-risk patients relapse and we have noted higher relapse rates during drug-free in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Breast Care
سال: 2008
ISSN: 1661-3805,1661-3791
DOI: 10.1159/000127220